Potassium Orotate®


Potassium Orotate® is a non-hormonal, anabolic agent, which is a potassium salt of carboxylic acid. It has a general stimulating effect on metabolic processes. It is a stimulant for the synthesis of nucleic acids involved in protein synthesis; it enhances reparative and regenerative processes in body tissues.

  1. Orotic acid enhances the formation of albumin in the liver, especially in case of prolonged hypoxia that occurs in some diseases, such as heart failure. It improves the tolerance to cardiac glycosides and increases diuresis.
  2. Potassium is another active substance of the drug which activates the benefits of orotic acid. It regulates water balance, stimulates muscle contraction and membrane potential. 
Indications for use:
  • Heart failure;
  • Muscle dystrophy;
  • Anaemia;
  • Therapy of hepatic pathologies;
  • Overexertion;
  • Stimulation of anabolic process.

Sometimes bodybuilders also use Potassium Orotate® for their purposes: muscle growth, cutting training, prevention of pathologies of the heart and blood vessels against intensive steroid courses.


Dosage and administration

Orally, before meal, 0.25-0.5 g 2-3 times a day. The course is 20–40 days.


Despite the fact that Potassium Orotate® is generally safe for the human body, in some cases its use is strictly prohibited:

  • Hepatic failure and pathologies (both chronic and acute);
  • Hypersensitivity to orotic acid and any of its derivatives;
  • Cirrhosis of the liver.

Side Effects

The drug is usually well tolerated. Though very rarely, side effect are manifested:

  • Allergic reactions (might occur when the drug is discontinued or after taking any antihistamine);
  • Dyspeptic disorder (the development of gout) is a clinically unproven phenomenon, but people with a tendency to such a pathology better refrain from taking Potassium Orotate®;
  • Mild gastrointestinal disturbance (often manifested in the form of nausea and vomiting);
  • Hepatic dystrophy (only if taken in large doses and accompanied by a diet with a small amount of animal protein).


There is no officially confirmed information about cases of overdose, but, according to athletes, skin manifestations in the form of itching, rash, as well as hyperkalemia are possible.


As for the positive interaction Potassium Orotate® goes well in combination with magnesium (cardiologists recommend taking such a combined course for cardiac pathologies). It reduces the body's intoxication of cardiac glycosides, increases the effectiveness of calcium and magnesium agents, and accelerates ion tolerance. If desired, Potassium Orotate® is perfectly supplemented by multivitamin complexes that will help increase energy potential and keep the body in good shape.