Piribedil [Pronoran]


Pronoran (Piribedil) is a drug used for more than four decades to treat Parkinson’s disease. Besides the symptomatic relief in Parkinson’s patients, Piribedil has shown to improve cognitive functions in healthy older adults.

The drug works by stimulating dopamine d2/d3 receptors and inhibiting alpha 2-adrenoceptors.

Indications for use are:

  • Age-related cognitive dysfunctions, such as memory and attention impairments
  • Parkinson’s disease
  • Symptomatic treatment of ocular ischemic syndrome

For further reading about Piribedil, you can visit Piribedil page on sciencedirect.com

Dosage and administration

The dosage for all indications except Parkinson’s disease is 50mg (one pill) once a day, in some cases 50mg twice daily.

The dosage for Parkinson’s disease is 150-250mg a day, split in three doses.

Side effects

  • Nausea
  • Delirium
  • Hallucinations
  • Agitation
  • Vertigo
  • Sleepiness
  • Hypotension
  • Allergic reactions


  • Hypersensitivity
  • Collapse
  • Acute myocardial infarction
  • Treatment with antipsychotics (except clozapine)
  • Age below 18 years old

Additional information

Since Piribedil in rare cases may cause pronounced sleepiness, it may affect the ability to drive and use machines. If such adverse effect occurs, consider lowering the dosage or cease the treatment with this drug.

The patients and their tutors should be warned that the drug may cause behavioral disorders such as gambling cravings, increased libido and hypersexuality, compulsive shopping and eating.

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