Phenibut (beta-phenyl-GABA) is a Russian anxiolytic, which is also known under the trade name of Noofen.

By its structure, Phenibut is a phenyl derivative of gamma-aminobutyric acid, the main inhibitory neurotransmitter in the central nervous system. Unlike GABA itself, Phenibut is able to penetrate the blood brain barrier and reach the brain when administered orally, thus producing an anxiolytic effect.

Phenibut is one of the most potent Russian anxiety drugs and is often used recreationally. Because of its huge recreational potential, some people take Phenibut at excessive dosages long-term. Such abuse may cause withdrawal syndrome after cessation, please follow instruction when taking Phenibut.

Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter GABA, which can cross the blood-brain barrier much better than the original compound.

Indications for use:

  • Emotionally labile disorders
  • Asthenic disorders (lack of energy)
  • ADHD in children
  • Alcohol withdrawal
  • Poor sleep quality in older patients
  • Lack of motivation
  • Other conditions characterised by reduced intellectual productivity

 Some short facts:

  • Instant anxiolytic effect.
  • Phenibut improves attention, memory, speed and accuracy unlike tranquillisers.
  • Improves motivation but might drain your willpower.
  • Small doses have calming and nootropic effects, while larger ones have stimulating effect.

Dosage and administration

The dosage recommended by the manufacturer is 250-500mg three times a day for 4-6 weeks. The maximum single dose is 750mg, for patients older than 60 years old – 500mg.

Side effects

  • Allergic reactions
  • Irritability
  • Anxiety
  • Vertigo
  • Headaches
  • Sleepiness
  • Nausea


  • Hypersensitivity
  • Age below 18 years old
  • Pregnancy and lactation