Pantogam Active [D,L-hopantenic acid]


Pantogam (hopantenic acid) is a nootropic drug currently used In Russia to treat chronic fatigue and various neurological diseases. The drug has neuroprotective, anxiolytic and anticonvulsant properties.

By its chemical structure, hopantenic acid is a derivative of pantothenic acid (Vitamin b5 form) and gamma-aminobutyric acid (the main inhibitory neurotransmitter in the CNS). Pantogam works by activating GABA-A, GABA-B, and dopamine D2 receptors and is shown to stimulate the synthesis of acetylcholine.

Indications for use include decreased mental capacity, chronic fatigue, organic brain syndrome and developmental delays in children.

Pantogam Active is a racemic modification of Pantogam. Hopantenic acid has two active Enantiomers, and Pantogam active has a different racemic composition with a higher content of L-enantiomer. Because of the different composition, Pantogam and Pantogam active have slightly different pharmacological effects. A modified version of this drug features more pronounced anxiolytic and anti-amnesic effects.

Indications for use are:

  • Organic brain syndrome;
  • Cerebrovascular insufficiency;
  • Extrapyramidal symptoms;
  • Epilepsy;
  • Decreased mental and physical capacity;
  • Neurogenic bladder dysfunction;
  • Developmental delays.

Pantogam can be taken also by healthy individuals to increase mental and physical capacity and to relieve asthenic symptoms such as chronic fatigue. It also may improve memory and attention.

Dosage and administration

The dug is used orally, 15-20 minutes after meals, 2-3 times a day, preferably in the morning or afternoon. 300 mg capsules - 1-3 capsules per one time (0.3 – 0.9 gr). Maximum daily dose - 9 capsules (2.7 g). The treatment period - 1-4 months, sometimes up to 6-12 months. After 3-6 months the treatment can be performed again.


  • hypersensitivity,
  • acute severe diseases of kidneys,
  • pregnancy (1st trimester),
  • lactation,
  • age below 18 years (lack of clinical data).

 Side effects

  • allergic reactions
  • sleeping impairments, somnolence, a noise in the head (short-lasting symptoms)


In case of overdose the side effects can increase. Treatment: charcoal, gastric lavage, symptomatic treatment.

Drug Interactions

Pantogam prolongs the effects of barbiturates, increases anticonvulsants effects, and prevents side effects of phenobarbitalum, carbamazepine, and neuroleptics. The efficiency of Pantogam Active® is increased in combination with glycine, or ethydronic acid. The drug potentiates the effect of local anesthetics (procaine).