Mildronate [Meldonium]


Mildronate (Meldonium) is a Soviet anti-ischemic drug primarily used to protect the heart from ischemic damage.

It is used to treat ischemic heart disease, cerebrovascular disorders, and asthenia (aka chronic fatigue). Mildronate also often used recreationally by many people as a performance enhancer, especially by athletes.

Meldonium works by inhibiting carnitine biosynthesis, thus preventing accumulation of fatty acid oxidation byproducts in tissues.

Indications for use:

  • Ischemic heart disease
  • Cerebrovascular disorders
  • Decreased mental and physical capacity
  • Alcohol abstinence syndrom

Interesting facts about Mildronate:

  • Latvia is selling about 70 million Euro of Mildronate annually, which is about 0.7% of the total exports of this country.
  • The creator of the drug, professor Ivars Kalvins, claims that Meldonium has never been found to have anabolic properties; it is rather a cardioprotector that can protect cardiovascular system of athletes from ischemia under high physical workloads. He also says, that, as such, most athletes actually should use it to diminish the negative effects associated with high-intensity trainings.
  • In 2015, 17% of Russian athletes were tested positive for Meldonium, compared with 2.2% athletes of other nationalities.
  • Like Semax and Cerebrolysin, Mildronate is on the Russian List of Vital & Essential Drugs.

    Dosage and administration

    The recommended dosage depends on diagnosis:

    • The dosage for Ischemic heart disease and cerebrovascular disorders is 500-1000mg daily, either in single or by two separate doses. The length of the treatment course is 4-6 weeks.
    • The dosage for performance increase is 500mg twice daily for 10-14 days. The course can be repeated in 2-3 weeks if necessary. For injection form, the dose is 5ml taken either by IV or IM injection once daily for 10-14 days.
    • The dosage for alcohol abstinence syndrome is 500mg four times a day for 7-10 days.

    Side effects

    • Allergic reactions
    • Indigestion
    • Tachycardia
    • Increased/decreased arterial pressure
    • Agitation
    • Drowsiness


    • Hypersensitivity
    • Increased intracranial pressure
    • Age below 18 years old
    • Pregnancy and lactation