Metadoxile [Metadoxine]


Metadoxine is a drug used for the treatment of alcohol intoxication. Recent clinical studies also suggest that it can be used as a non-stimulant ADHD medication.

Metadoxine is a salt of pyridoxine (vitamin B6 form) and pyrrolidone carboxylate. The drug does promote the metabolic degradation of ethanol and restore the functional state of the liver, thus decreasing the toxic effect of alcohol on the brain and body.

According to the results of the clinical trial published in 2012, extended release version of Metadoxine showed a significant improvement of ADHD symptoms in adult patients.

The official indications for use are:

  • Prophylaxis of alcohol-induced liver diseases
  • Acute alcohol intoxication
  • Chronic alcoholism
  • Alcohol abstinence syndrome

Dosage and administration

The dosage for the treatment of liver disorders and chronic alcoholism is one pill twice daily, 15-30 minutes before a meal. The dosage can be raised to 1500 mg/day. The treatment course should be not less than 90 days long.

Side effects

  • Allergic reactions
  • Bronchospasm in asthmatic patients (if administered in injection form)


  • Hypersensitivity
  • Pregnancy and lactation

Metadoxine should be taken with caution by Parkinson’s patients treated with levodopa, as the drug does decrease its therapeutic effect.