Metadoxile [Metadoxine]


Metadoxine is a drug used for the treatment of alcohol intoxication. Recent clinical studies also suggest that it can be used as a non-stimulant ADHD medication.

Metadoxine is a salt of pyridoxine (vitamin B6 form) and pyrrolidone carboxylate. The drug does promote the metabolic degradation of ethanol and restore the functional state of the liver, thus decreasing the toxic effect of alcohol on the brain and body.

In clinical studies, metadoxine has been reported to reduce half-life of ethanol in healthy volunteers and in acutely intoxicated patients; to accelerate the metabolism of alcohol and acetaldehyde into less toxic higher ketones and to improve their urinary clearance; to restore laboratory variables such as alcohol, ammonia, γ-GT, and alanine aminotransferase; and to improve clinical symptoms of alcohol intoxication, including psychomotor agitation, depression, aggressiveness, and equilibrium disorders.

According to the results of the clinical trial published in 2012, extended release version of Metadoxine showed a significant improvement of ADHD symptoms in adult patients.

Indications for use

Metadoxil® tablets:

  • Complex therapy of liver diseases, especially of alcohol etiology;
  • Chronic alcoholism.

Metadoxil® ampoules:

  • Acute alcohol intoxication;
  • Alcohol withdrawal syndrome.

Dosage and administration

The drug is prescribed as part of the complex therapy of liver diseases and chronic alcoholism in the amount of 500 mg (1 tablet) 2 times a day 15-30 minutes before meals. The dose can be increased to 1500 mg (3 tablets) per day if necessary. The course of treatment is at least 90 days.
In acute alcohol intoxication, the drug is administered i/m in the amount of 300-600 mg (5-10 ml) or i/v in the amount of 300-900 mg (5-15 ml) depending on the severity of intoxication. In case of the intravenous mode of administration, the desired dose of the drug is dissolved in 500 ml of saline or in a 5% glucose solution and is administered by drop infusion for 90 minutes.
In case of alcohol withdrawal syndrome the drug is administered i/v in the form of an infusion at a dose of 900 mg (15 ml) 1 time / during 4-7 days, depending on the patient's condition.

Side effects

  • Allergic reactions;
  • Bronchospasm in asthmatic patients (when using an injection).


  • Pregnancy and lactation;
  • Hypersensitivity to the drug components.

The drug should be prescribed with caution in case of Parkinson's disease if Levodopa is used at the same time, because metadoxine reduces the effectiveness of the latter.