Melarena [Melatonin]

$7.49

Melarena is an adaptogen, sedative and hypnotic drug based on a synthetic analogue of pineal hormone melatonin. It is used in case of jet lag, adjusts sleep-wake cycles and helps blind people establish a day and night cycle. It stabilizes circadian rhythms.

It increases levels of gamma-Aminobutyric acid and serotonin in the midbrain and hypothalamus as it regulates the pyridoxal kinase which influences the synthesis of these compounds. The drug inhibits the secretion of gonadotropins and other pituitary gland hormones (corticotropin, thyroid stimulating hormone and somatotropin). It normalizes daily changes in body activity and temperature, improves brain activity and reduces irritability. It helps fall asleep, reduces night time awakenings and facilitates morning awakening.

Indications

Prevention and treatment of:

  • desynchronosis (alterations to the body's circadian rhythms caused by rapid long-distance trans-meridian (east–west or west–east) travel or working shifts and jet lag);
  • weather sensitivity;
  • fatigue and sleep disorders;
  • depression.

Contents

Coated tablets, dosage 0.3 mg and 3 mg

Active ingredient: synthetic melatonin 0.3/3 mg

Inactive ingredients: calcium hydrophosphate dihydrate 67.37 mg, microcrystalline cellulose 25 mg, sodium croscarmellose 2 mg, povidone K25 3.33 mg, fumed silica 0.5 mg, talc 1 mg and calcium stearate 0.5 mg.

Dosage and administration

To be administered orally. The dosage is 1 tablet daily 30-40 minutes before sleep. Duration of treatment course is to be prescribed by a doctor (6-8 weeks). If necessary, the treatment courses can be repeated.

The dose of 0.3 mg is sufficient in most cases.

Side Effects

  • allergic response,
  • headache,
  • nausea,
  • vomiting,
  • diarrhea,
  • morning sleepiness,
  • edema.

 

Drug Interaction

Melarena is incompatible with monoamine oxidase inhibitors, glucocorticoids and cyclosporine.
It enhances the effect of CNS depressants and beta blockers.

It is not recommended to co-administer Melarena with nonsteroidal anti-inflammatory and hormonal drugs.