Hypoxenum is an adaptogen with an active compound of Hypoxen is Sodium salt of (poly-(2,5-dihydroxy-phenylene))-4-thiosulfonic acid. Hypoxenum and coenzyme Q10 have a similar structure.

Hypoxen was shown to have antihypoxic and antioxidant effect and can be used by healthy people with reduced performance in extreme situations and adverse weather conditions. Apart from that, the drug was also shown to be effective in patients suffering from alcohol abuse problems as it can decrease cravings, improve mood, lower anxiety and asthenia. 

Off-label use of Hypoxenum includes treatment of patients with addictive disorders such as the relief of alcohol withdrawal. As was shown in this study Hypoxenum possesses high efficacy as a drug used to relief withdrawal symptoms in the period of postabstinence.

The active compound of the drug is also patented in the USA: https://patents.google.com/patent/US6117970A/en

Pharmacodynamic properties

Hypoxenum prevents lipid peroxidation and stimulates its products destruction. It stimulates the oxidation of accumulated reduced equivalents during the post-hypoxic period due to Nicotinamide adenine dinucleotide phosphate or NADP⁺. It optimises mitochondrial function, enhances tissue respiration and mitochondria aerobic respiration, reduces the hypoxia negative effects as a result increasing endurance and mental performance.

Pharmacological effect

Antihypoxic and antioxidant effects. Hypoxenum has electron acceptor properties due to its polyphenolic structure, shunts the electron transport chain of mitochondria and enhances tissue respiration. The thiosulfate group gives Hypoxenum a pronounced antiradical and antioxidant effect.

Dosage and administration

Hypoxenum dosage is calculated individually based on the patient’s needs, body weight and indications.

Body weight, kg Daily dose, capsules
60–70 3–4
70–80 4–6
80–90 6–8
90–100 8–10
100–120 10–12

One daily dose 30–60 minutes before exercise should be taken to treat hypoxia in the following situations:

  • alveolar hypoventilation;
  • highlands;
  • underwater work;
  • working in high temperatures;
  • endurance training.

One-half daily dose 2 times a day for 2-3 weeks should be taken in the following situations:

  • long-term intense mental activity;
  • chronic fatigue;
  • reducing the recovery period after excessive physical exertion;
  • injuries and surgery.

*** Administration of two pills per day for 14 days was shown to be effective for the alleviation of alcohol withdrawal symptoms.

Side effects

Allergic response.


Main symptoms: abdominal pain, nausea, dry mouth and respiratory depression in rare cases.

Treatment: gastric lavage, activated carbon administration and symptomatic treatment.