Heptor [S-Adenosyl methionine]


Heptor is a drug based on ademetionine (S-Adenosyl methionine), which is currently considered one of the most powerful hepatoprotectors.  Apart from its hepatoprotective properties, ademetionine also has anti-inflammatory, painkiller and antidepressant effects. 

Heptor also has detoxifying, regenerating, antioxidant, antifibrotic and neuroprotective properties.

The drug was shown to be effective in patients with hepatopathy caused by hepatotoxic drugs.

The use of Heptor in patients with opioid addiction accompanied by liver damage helps reduce manifestations of withdrawal symptoms and improves the functional state of the liver.

Antidepressant effects of the drug increase gradually starting from the 2nd week of the treatment course. Research demonstrated that the drug is effective in treating depression relapse.


  • hepatitis of various origins: toxic, viral, drug-induced (caused by antibiotics, anticancer drugs, anti-tuberculosis and antiviral drugs, tricyclic antidepressants and oral contraceptives);
  • intrahepatic cholestasis;
  • cirrhosis;
  • secondary metabolic encephalopathy;
  • depressive disorder;
  • alcohol withdrawal syndrome.


    Enteric coated tablets, 20 tablets per pack.

    Active ingredient: ademetionine 400 mg

    Inactive ingredients: crospovidone 19 mg, microcrystalline cellulose 53 mg, mannitol 53 mg and magnesium stearate 15 mg.

    Pharmacodynamic properties

    As a hepatoprotector, Heptor replenishes ademetionine deficiency and stimulates its production in brain and liver. As a part of transmethylation, it elevates glutamine levels in the liver and increases plasma cysteine and taurine concentration. It also lowers the concentration of methionine in serum; this helps stabilize the metabolic functions of the liver. Heptor acts as a precursor of polyamines: putrescine which stimulates cell regeneration, spermidine and spermine that are compounds of ribosomes and living tissues.

    Choleretic effect of the drug is driven by synthesis of phosphatidylcholine in hepatocyte membranes which increases their mobility. This enhances the function of biliary system. The drug is effective in case of bile secretion disorders, including cholestasis.

    Dosage and Administration

    The average daily dose is 800–1,600 mg (2-4 pills). The treatment period duration is 2-4 weeks.

    Drug interaction

    To be used with caution when co-administered with selective serotonin reuptake inhibitors, tricyclic antidepressants or drugs containing tryptophan.


    • genetic disorders affecting the methionine cycle and/or causing homocystinuria/hyperhomocysteinemia;
    • children under 18 years of age;
    • hypersensitivity to the components of the drug.

    Side effects

    • In the digestive system: nausea, abdominal pain or diarrhea.
    • In the nervous system: insomnia or headache.
    • Allergic response.