Grandaxin [Tofisopam]


Grandaxin is a 2,3- benzodiazepine derivative and belongs to the novel class of drugs called homophthalazines. Tofisopam does not cause sedation or cognitive functions impairments; moreover, it may produce a moderate stimulative action, possibly by increasing the sensitivity of dopaminergic receptors. The drug does not form an addiction.

Grandaxin does not impair cognitive functions; moreover, it has a mild stimulant action and is able to potentiate the effect of dopaminergic stimulants.

Tofisopam has a complicated mechanism of action. It does not bind to benzodiazepine receptors and has a limited affinity to the peripheral benzodiazepine receptors, but shown to improve the binding of 1,4-benzodiazepines to their receptors.

The drug acts as a PDE inhibitor with highest affinity to PDE-4A1, PDE-10A1, PDE-3 and PDE-2A3 which can be responsible for its moderate antipsychotic action.


  • Conditions followed by emotional tension, anxiety, apathy, and obsessive worrying
  • Reactive depression
  • Post-traumatic stress disorder
  • Menopause (as a standalone therapy or as adjuvant therapy with hormonal preparations)
  • Premenstrual syndrome
  • Alcohol abstinence syndrome

Dosage and administration

The dosage is 1-2 pills 1-3 times a day, the maximum daily dosage is 300mg. If taken occasionally, the dosage is 1-2 pills. Aged patients and patients with renal insufficiency should cut the dosage in half.

Side effects

  • Side effects on digestive system: loss of appetite, constipation, nausea, dry mouth.
  • Nervous system: headaches, insomnia, irritability, agitation, delirium, may provoke seizures in epileptic patients.
  • Allergic reactions
  • Muscle tension
  • Respiratory depression


  • Hypersensitivity
  • Conditions followed by psychomotor agitation, aggression or pronounced depression
  • Decompensated respiratory failure
  • Pregnancy and lactation
  • Sleep apnea
  • Coadministration with Tacrolimus, Sirolimus, or Cyclosporine
  • Lactose intolerance

These reviews have been taken from the Russian website

★★★★★ (5/5)

As a person with a volatile temper, I am prone to stress and anxiety. A long road trip, college, then pregnancy, then my husband was recruited to the army. All this has accumulated over time. And one day, when everything seemed to be good, my husband and child were with me, my nerves gave up. I fell into depression. Never experienced it before. Each day my condition gets worse, I eat nothing, left the college, didn’t care about my kid… Everything started going to hell. Went to a doctor but he didn’t

And one day, when everything seemed to be good, my husband and child were with me, my nerves gave up. I fell into depression. Never experienced it before. Each day my condition gets worse, I eat nothing, left the college, didn’t care about my kid… Everything started going to hell. Went to a doctor but he didn’t

Everything started going to hell. Went to a doctor but he didn’t help much.  So I decided to visit a psychiatrist. His diagnosis was: moderate depression with anxiety disorder and exhausted nervous system. He suggested antidepressant for me, but I refused it. Then he offered Grandaxin which pulled me out of this terrible condition.

The drug starts to act after two hours after ingestion.  It brings the feeling of indifference and relieves anxiety. I was prescribed with one pill twice daily. But then I experienced side effects like the apathetic feeling in the first half hour, then slight difficulties breathing, after about an hour these problems goes away and you simply start to see this world from a different angle. Doctor suggested to take half of the pill four times a day, we’ll see what happens. For now I took it for three days and already noticed that it helps me with my depression. My hands no longer shaking from nerves, I stopped crying, became more active and started to come back to life.

Grandaxin was prescribed along with the other medications and vitamins. A very good drug. If your doctor prescribed it for you – take it. I will finish the course and will tell how it helped.


★★★★★ (5/5)

The doctor prescribed for me Paxil and Grandaxin because of my panic attacks. I decided not to take Paxil because of its huge list of side effects but decided to try Tofisopam. The main problem is the fear of going outside in the morning, the fear was so intense that I always reached my car in presyncope. You need to take two pills daily, one at the morning and one at the lunch, it is not recommended to take it later to avoid sleeping problems. In the first week, I think I felt worse but later I started to feel the effect. I became calmer, less fearful, not suffer from racing heart as much as before, noticed an overall improvement. At least I can reach my car without any problems now which is already good. Taken it for 20 days, now took a break and I think I will take another 20-day course in April, despite my doctor’s suggestion that I can take it for three months without a break. So, my opinion is that this drug helps but does not relieve panic attacks completely. I suggest you hold the breath and let it out slowly, then repeat, it calms you down fast.


★★★★☆ (4/5)

It happened so that all my problems and troubles fell on me simultaneously. Irritability showed up at first, then a mental breakdown, and as a result – insomnia. Even after a hard day full of physical work I was able to fall asleep because of my exhaustion, but not for long. Woke up midnight, with a head full of bad thoughts, and I could just lay in the bed until morning without falling asleep. Of course, at the morning I was broken, tired, with terrible mood. I even had a fever sometimes, that’s so unpleasant! Novo-Passit no longer helps, just as other sedatives like motherwort or valerian root.

Thankfully, my daughter-in-law visited me and suggested to try Grandaxin. I inspected the package insert carefully and decided to take two pills. As for me, this drug helped immediately. I calmed down, can’t say I calmed down completely but my anxious state has gone, I wasn’t nervous about, and what’s the main thing, is that my sleep has normalized. I could not believe my eyes as it was 6 AM when I woke up. Before that, I could sleep only until 3 AM. Started to think less about bad things, my overall condition improved.

It is recommended to take Grandaxin by courses, but I afraid to become dependent on it, so I stopped taking it and will see what happens next. So, for people who have the same symptoms, I suggest to try Tofisopam after consulting with a doctor.


★☆☆☆☆ (1/5)

I heard about Grandaxin long time ago and saw lots of feedbacks. Recently I started to suffer from panic attacks. Went to a doctor and he prescribed this drug for me. Took it for four days, couldn’t take it anymore, didn’t notice anything but side effect. The side effects I’ve noticed is complete loss of appetite, excess saliva production and the panic attacks only got more frequent.


★★★★★ (5/5)

That’s a good tranquilizer which is available without a prescription. It has a cumulative action, and the only side effect is sleepiness after taking more than two pills in three hours period. After a short nap this effect disappears, but still, it’s better not to take too much or drive a car after taking it. I tried Grandaxin in a stressful situation when I was told that my friend had died. It kicked in about 15 minutes after ingestion, felt a feeling of indifference. It did not affect my actions, I was able to think clearly as before, but my emotional pain has relieved.

The drug is good, I took it regularly for three days and then stopped, but the effects lasted for three days more, calming down my emotions. No negative consequences after that, no drowsiness, sleepiness or any problems with health. If you, god forbid, experience stress – try Grandaxin as a tranquilizer, I liked it.