Ethoxidol [Ethylmethylhydroxypyridine Malate]


Ethoxidol is a combination drug that inhibits free radical processes and has antioxidant, membrane-protective, anti-hypoxic, nootropic, anti-convulsant, anxiolytic and stress-protective effect. It contains ethylme-thylhydroxypyridine malate and other active ingredients such as dimethylethanolamine (DMAE), N-Acetyl-DL-glutamic acid and glycine.

Ethoxidol can be used in anti-ischemic therapy as it stimulates blood flow in the penumbra. It also reduces total cholesterol and low-density lipoproteins.

The drug increases resistance towards various damaging factors, as well as pathological conditions such as shock, hypoxia, ischemia, cerebrovascular ac-cidents and intoxication with alcohol and antipsychotics (neuroleptics).


  • as part of complex therapy of coronary heart disease;
  • as part of complex therapy of ischemic stroke;
  • encephalopathy;
  • mild to moderate cognitive impairment.



    Active ingredients: ethylmethylhydroxypyridine malate 100 mg, N-Acetyl-DL-glutamic acid 68 mg, dimethylethanolamine 32 mg and glycine 20 mg;

    Pharmacodynamic properties

    Ethoxidol’s effect is driven by its antioxidant, anti-hypoxic and membrane-protective properties. It inhibits lipid peroxidation, increases the lipid-protein ratio, stabilizes the membrane fluidity and stimulates the membrane-bound enzymes and receptors.

    Pharmacokinetic properties

    After ingestion, the drug is absorbed from the gastrointestinal tract and gets distributed to the organs and tissues of the body. It stays in the blood plasma for 7-10 hours. Then Ethoxidol is extensively metabolized in the liver.

    Dosage and application

    Oral administration, chewable tablets.

    As part of complex therapy of coronary heart disease, the recommended dosage is 1 tablet (100 mg) 3 times a day. The maximum single dose is 200 mg, the maximum daily dose is 800 mg. The minimum recommended treatment course is 2 months. 

    As part of complex therapy of mild or moderate cognitive impairment, the recommended dosage is 1 tablet (100 mg) 3-4 times a day with no limit to the duration of treatment.


    • hypersensitivity,
    • lactose intolerance and lactose deficiency,
    • glucose galactose malabsorption,
    • acute kidney injury,
    • acute liver failure,
    • children under 18 years of age,
    • pregnancy and lactation.

    Side effects

    • allergic reactions;
    • dyspeptic disorders;
    • nausea;
    • dry mouth;
    • diarrhea. 

    Drug interaction

    Ethoxidol enhances the effect of anticonvulsant drugs (carbamazepine), antiparkinson medication (levodopa) and benzodiazepine anxiolytics. It also re-duces the toxic effects of ethanol.