Mirapex [Pramipexole]


Mirapex (Pramipexole) is a dopaminergic drug used to treat Parkinson’s disease and restless leg syndrome. Several studies also suggest that the drug has antidepressant, neuroprotective, and neurotrophic properties.

Pramipexole is a dopamine receptor agonist and is shown to promote survival of dopaminergic neurons by stimulating the release of endogenous neurotrophic factors BDNF and GDNF.

In the clinical trial on 174 patients with the major depressive disorder, patients that received Pramipexole had a significant improvement in their depressive symptoms.

Dosage and administration

The initial dosage is 0.375mg which can be raised every 5-7 days until the desired clinical effect is reached. The maximum daily dose is 4.5mg.

The daily dosage should be split into three doses, extended release pills should be taken only once daily.

Side effects

  • Abnormal behavior, such as compulsive buying disorder, overeating, and hypersexuality
  • Strange dreams, hallucinations, delirium
  • Headaches
  • Hypotension
  • Pneumonia
  • Allergic reactions
  • Insomnia
  • Anxiety


  • Hypersensitivity
  • Age below 18 years old

Dopaminergic drugs have numerous side effects and should be taken with action. For further reading about the side effects, safety and dosing please visit Mirapex instruction on drugs.com