Sildenafil-FPO is a drug used to treat erectile dysfunction and pulmonary arterial hypertension. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis.
The primary indication of Sildenafil is a treatment of inability to sustain a satisfactory erection to complete intercourse. It is used as one of the standard treatments for erectile dysfunction. It can be even used by men with diabetes as well as men who experience antidepressant-induced erectile dysfunction.
Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon; these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes.
Indications for use
The half-life of sildenafil is 3-5 hours.
Orally. The recommended dosage for most patients is 50 mg 1 hour before sexual activity. Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.