Sildenafil-FPO is a drug used to treat erectile dysfunction and pulmonary arterial hypertension. Sildenafil acts by blocking phosphodiesterase 5 (PDE5), an enzyme that promotes breakdown of cGMP, which regulates blood flow in the penis

The primary indication of Sildenafil is a treatment of inability to sustain a satisfactory erection to complete intercourse. It is used as one of the standard treatments for erectile dysfunction. It can be even used by men with diabetes as well as men who experience antidepressant-induced erectile dysfunction.

Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon; these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes.

 Indications for use

  • Sexual dysfunction
  • Pulmonary hypertension
  • Raynaud's phenomenon
  • High-altitude pulmonary edema
Sildefanil is a Russian-manufactured high quality product at a reasonable price that contains the same active ingredient as Viagra.

1 tablet contains sildenafil citrate 140.45 mg (sildenafil 100 mg)

 The half-life of sildenafil is 3-5 hours.

Dosage and administration

Orally. The recommended dosage for most patients is 50 mg 1 hour before sexual activity.  Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended dosing frequency is once per day.



  • hypersensitivity to the components of the drug;
  • severe liver failure;
  • concomitant use of ritonavir;
  • severe cardiovascular disease;
  • patients with episodes of development of non-arteritic anterior ischemic optic neuropathy with loss of vision in one eye;
  • hereditary retinitis pigmentosa;
  • age below 18 years.

    According to the indications, Sildenafil-FPO® is not intended women.