Polyoxidonium is a medicine intended for stimulating the immune system. Its active ingredient is azoximer bromide (copolymer N-oxide 1,4-ethylene piperazine and (N- carboxymethyl)-1,4-ethylene piperazinium bromide).

Polyoxidonium has a complex effect as it is an immunomodulator with detoxifying and antioxidant properties. It restores immunity and detoxifies, thus improving patients’ general condition as well as reducing the risk of developing complications. 

Polyoxidonium in intranasal form can be used in children from six months of age, which proves its safety.

The manufacturer's official website – polyoxidonium.ru

The drug can be applied orally, intranasally or intramuscularly.


  • seasonal prevention of exacerbation of chronic conditions and prevention of URI (upper respiratory infection) and influenza during the pre-epidemic period;
  • treatment of secondary immunodeficiencies caused by ageing or adverse factors;
  • prevention of recurrent herpetic infection.


Tablets: Azoximer bromide 12 mg


Dosage and application

Influenza and URI treatment course lasts 7 days.

Tablets: Apply orally and sublingually 20-30 minutes before meal twice a day. Dosage for adults and children from 10 years of age is 1 tablet, dosage for children aged 3 to 10 is 1/2 tablet (6 mg).

If necessary, treatment courses can be repeated after 3-4 months. Effectiveness is not reduced on repeat prescription.

Vials: For intramuscular injection dilute 3 mg of Polyoxidonium in 1 ml (6 mg in 2 ml) of water for injections or 0.9% sodium chloride solution. After the dilution leave for 2-3 minutes and then stir without shaking.

Preparing a solution for intranasal or sublingual administration: for use in children dilute 3 mg dosage in 1.0 ml (20 drops), 6 mg dosage in 2.0 ml (40 drops) (1 drop (0.05 ml) of prepared solution contains 0.15 mg of the drug); for use in adults dilute 6 mg dosage in 1.0 ml (20 drops) of 0.9% sodium chloride solution or boiled water.

Parenterally (intramuscular or intravenous): dosage for adults is 6-12 mg once a day daily, every other day or 1-2 times a week depending on the diagnosis and disease severity.

Daily doses for children (intranasal or sublingual administration): 1 drop per 1 kg, but no more than 40 drops (6 mg of the active ingredient).

A prepared solution for intranasal or sublingual administration can be stored at room temperature in manufacturer’s package for up to 48 hours.


  • individual hypersensitivity;
  • acute kidney insufficiency;
  • pregnancy (no application experience);
  • lactation;
  • children under 3 years of age (tablets);
  • lactose intolerance, lactase insufficiency and glucogalactose malsorbtion.

 Drug interaction

Azoximer bromide does not inhibit CYP1A2, CYP2C9, CYP2C19 and CYP2D6 isoenzymes, so Polyoxidonium can be administered with antibiotics, antivirals, antifungal and antihistamine preparations, glucocorticoids, and cytostatics.

Storage conditions

Keep out of the reach of children. Store at 2-25°С (35,6 - 77) °F.