Many of the experienced Nootropics users have heard of Tenoten. As manufacturers and vendors claims, it is an anti-anxiety supplement with some nootropic activity. Those who want to try it faced the problem of availability – most vendors are not US-based. They ship directly from Russia, and that means high shipping costs and time, and possible problems with customs. So, there is not much info available about it in the English part of the internet, since not many people have tried it.
In this post, I’ll try to shed light on this nootropic for the English-speaking Nootropics user community.
WHAT TENOTEN IS AND HOW IT WORKS
Tenoten is a novel homeopathic anxiolytic with mild nootropic and antidepressant activity. The active ingredient is antibodies to brain-specific protein S100 that is expressed and secreted by astrocytes and microglial cells.
Tenoten acts as anxiolytic by interacting with GABA-A receptors and the opening of a chloride ion-selective channels. The drug modulates synaptic plasticity and increases brain resistance to hypoxia. It also improves cerebral blood flow, thus having some impact on cognition.
The studies of the impact of S100 protein and its antibodies on the nervous system began in the 1960’s. During these researches, it was found that the low dosages of S100 antibodies can be used for the treatment of certain dependencies. And in 2001 the new drug was released – ProProTen 100.
Proproten marketed as a remedy for hangover relief, and the treatment for alcohol dependence. One of the claimed effects is reducing the urge to drink alcohol.
The active ingredient of Proproten-100 is the same as Tenaten – S100 antibodies. They are, in fact, the same drugs. The only difference is the product form and concentrations.
Tenaten available only in pill form for sublingual administration, in two variations – Tenoten for kids, with 10x smaller concentration of active ingredient, and standard adult version. The concentration is 10^-15 ng/g.
Proproten-100 is available in drops and pills form. The reason why alcoholism version of this drug available in the liquid form, is that you can treat an alcohol-addicted person without his permission, adding a few drops in his food or drinks. The concentration in Proproten is 10^-1991 ng/g.
The further researches of the substance revealed anxiolytic and antidepressant properties of S100 antibodies. And then a new drug comes to the market –Tenoten. Same active ingredient, but different indications for use and concentration. This time is was marketed as mild and safe anxiolytic with antidepressant and nootropic action.
THERE ARE EVEN MORE REMEDIES WITH S100 ANTIBODIES FROM THE SAME MANUFACTURER!
The drug Brizantin marketed as quit smoking pills. It contains twice more S100 diluted antibodies by weight, and antibodies to Cannabinoid type 1 receptor. The drug Dietressa from this manufacturer also contains antibodies to cannabinoid receptors (but without S100 antibodies), marketed as weight loss supplement.
The drug Divaza contains antibodies to S100 protein like Tenoten, and Antibodies to Endothelial Nitric Oxide Synthase (eNOS). This one marketed as Nootropic supplement that increases cognitive functions and motivation. The claimed effects include sleep improvement, headaches relief, anxiolytic and antidepressive action. Another drug, Impaza, contains eNOS antibodies without S100 and sold as a prevention of erectile dysfunction.
Kolofort contains the antibodies to the following substances: S100, human tumor necrosis factor alpha, Histamine. This remedy marketed as a treatment of intestinal diseases.
The fact that they sell same substances in the different wrappings seems suspicious.
- Relief of anxiety symptoms.
- Antidepressant effect.
- Improve sleep.
- Mood improvement.
- No side effects.
Those who left negative feedback usually don’t mention any side effects. They didn’t notice any effect at all. I analyzed about 50 reviews, and near one-third of them stated that the drug was the useless waste of money. Only a few people reported dizziness and emotional numbness as a SE, although the drug leaflet says there are no side effects besides individual allergic reactions.
The reviews for Proproten-100 are mixed too. As the drug to reduce the alcohol craving, results mostly unsatisfying. Wives use it as a treatment of their husband’s alcoholism. And in some cases, it works, and the urge to drink disappears, sometimes not. Disulfiram and Cyanamide-based remedies definitely work better at this point.
The other effect of ProProTen, the alcohol hangover relief, seems more pronounced. Almost every review author admits that it really helps after a drinking binge.
STUDIES AND CLINICAL TRIALS
The title of the study is “Potentiated antibodies to brain-specific proteins s100: Impact on the biogenic monoamines and lipid peroxidation in alcoholized rats.”
The goal of this study was to evaluate the effect of S100 protein antibodies on the brain.
Rats received 25% ethanol solution at the 1.5-2 g/kg dosage for 15 days. After the cessation of ethanol, a part of alcoholized rats received 0.1 ml of S100 antibodies at the C1000 concentration, twice daily for seven days.
After that, both groups of rats they were decapitated. The content of neurotransmitters and their precursors in hypothalamus, hippocampus, amygdala, frontal cortex region and blood was measured to find the changes.
In alcoholized rats that did not receive treatment, norepinephrine and epinephrine content in the hypothalamus was 45% and 29% lower, respectively, compared to intact rats. At the hippocampus, the dopamine, norepinephrine, and epinephrine levels were increased by 2.5-4 times. Those changes clearly indicate hyperdopaminergic state and agitation.
Those changes in rats who received S100 treatment were less pronounced. Their levels of catecholamines in blood plasma also revealed the anxiolytic activity of the drug. And one thing to mention is that one of the authors of the study is specialized on homeopathy and related to the manufacturer.
The title of the next study is: “The psychological component of quality of life in patients with circulatory encephalopathy of the I-II stages during treatment with Tenoten."
The study was performed on two groups of 30 Patients each, with a diagnosis of cerebral atherosclerosis. The main group received standard treatment combined with Tenoten, while the control group received only standard treatment. The standard treatment includes medications for cerebral blood flow improvement (Vinpocetine/Ginkgo Biloba extract) and antiplatelet drugs (Aspirin/Clopidogrel).
Their psychological well-being was estimated by the following tests:
- Psychological General Well-Being Index.
- Center for Epidemiologic Studies Depression Scale.
- Hamilton Depression Rating Scale.
- Montgomery-Asberg Depression Scale.
- Hospital Anxiety and Depression Scale.
- Hamilton Anxiety Rating Scale.
You can see the results of the treatment at those infographics. The group who took Tenoten with their standard treatment feels a bit better than the control group. The difference, however, is not big. Also, there was no treatment+placebo group, would be interesting to compare.